B-NDG hB2M/HLA-A11.1 mice plus_Biocytogen Pharmaceuticals (Beijing) Co., Ltd._Biocytogen, drug development, antibody discovery

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동물/세포 모델

동물/세포모델

Immunodeficient Mice/Rats

Immunodeficient (B-NDG) Mice

Text

B-NDG hB2M/HLA-A11.1 mice plus

Strain Name

NOD.CB17-Prkdc^scid Il2rg^tm1Bcgen Igs2^{tm1(HLA-A2.1-B2M/HLA-A11.1)Bcgen}

H2-K1^tm1Bcgen H2-D1^tm1Bcgen/Bcgen

Common Name

B-NDG hB2M/HLA-A11.1 mice plus

Background

B-NDG

Catalog number

112474

Aliases

IMD43; HLAA

Protein expression analysis

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Strain specific B2M expression analysis in wild-type B-NDG mice and homozygous B-NDG hB2M/HLA-A11.1 mice plus by flow cytometry. Splenocytes, blood cells and bone marrow were collected from wild-type B-NDG mice and homozygous B-NDG hB2M/HLA-A11.1 mice plus, and analyzed by flow cytometry with species-specific anti-B2M antibody. Mouse B2M was detectable in wild-type mice but not in homozygous B-NDG hB2M/HLA-A11.1 mice plus. Human B2M was exclusively detectable in homozygous B-NDG hB2M/HLA-A11.1 mice plus but not in wild-type mice.

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Strain specific HLA-A expression analysis in wild-type B-NDG mice and homozygous B-NDG hB2M/HLA-A11.1 mice plus by flow cytometry. Splenocytes, blood cells and bone marrow were collected from wild-type B-NDG mice and homozygous B-NDG hB2M/HLA-A11.1 mice plus, and analyzed by flow cytometry with species-specific anti-HLA-ABC antibody and anti-H2-K1/H2-D1 antibody. Mouse H2-K1/H2-D1 was detectable in wild-type mice but not in homozygous B-NDG hB2M/HLA-A11.1 mice plus. Human HLA-A was exclusively detectable in homozygous B-NDG hB2M/HLA-A11.1 mice plus but not in wild-type mice.